Herbal plants from Riau Province as inhibitors of COVID-19 binding to ACE2 receptor by computer aided molecular design an in-silico method

Corona Virus Disease (COVID-19) is announced as pandemic by World Health Organization (WHO) since 11th March 2020. Riau Province has many herbal plants e.g. Cheilocostus specious, Euphorbia hirta l, Cassia torra, Bryophyllum pinnatum, Daniella ensifollia, and Ziziphus mauritiana that can cure diseases there not report yet focusing on in-silico method using SARS-CoV-2 protease (PDB ID:6LU7). This study aims to reveal the potential of compounds contained in Herbal Plants anti through its binding protein receptors. The was conducted molecular docking Autodock Vina 1.5.6 drug ability studies Swiss ADME. results six active including diosgenin, tannin, triterpenoid, chrysophanol, flavone phytosterol were -8,3; -7,5; -7,2; -6,9; -6,9 respectively against affinity result for natural ligand COVID-19 (-6,1). indicates stronger bond between ACE2 inhibitors because value are higher than COVID-19. SwissADME show triterpenoid tannin violate some Lipinski Rules make their drug-likeness low. In general, all candidates antiviral but most one diosgenin specious.